GNE-7883, CAS 2648450-42-2

Product Description: GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1].

Formula: C28H29FN6O2

References: [1]Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828.

CAS Number: 2648450-42-2

Molecular Weight: 500.57

Compound Purity: 98.49

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: YAP

• SKU: MEXHY-147214-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-147214-10.1
• Green Labware: No
• Package Unit: 10mM/1mL
• Quantity Unit: STK