GSK-3β inhibitor 16

Product Description: GSK-3β inhibitor 16 (compound 7c) is a GSK-3β inhibitor with the IC50 of 4.68 nM. GSK-3β inhibitor 16 decreases Tau hyperphosphorylated aggregate and alleviates cognitive impairments in the Scopolamin (HY-N0296)-induced model in mice[1].

Formula: C18H17N3O3

References: [1]Abdo Moustafa E, et al. Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer's disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation. Bioorg Chem. 2024;146:107324.

Molecular Weight: 323.35

Research Area: Neurological Disease

Target: GSK-3;Tau Protein

• SKU: MEXHY-161458-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161458-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK