GSK_WRN3, CAS 2923009-50-9

Product Description: GSK_WRN3 is a selective inhibitor of WRN protease (IC50 = 8.6 μM). GSK_WRN3 displays a high degree of selectivity by forming a covalent binding to the Cys727 residue of the WRN protein. GSK_WRN3 reduces growth support for MSI tumor cells by inhibiting WRN protease activity, resulting in increased DNA double-strand breaks and cell growth inhibition[1].

Applications: Cancer-programmed cell death

Formula: C16H20N2O5S

References: [1]Picco G, et al. Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. Cancer Discov. 2024 Apr 9.

CAS Number: 2923009-50-9

Molecular Weight: 352.41

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-162471-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162471-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK