GSK837149A, CAS 13616-29-0

Product Description: GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C23H22N8O5S2

References: [1]Vázquez MJ, et al. Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction. FEBS J. 2008 Apr;275(7):1556-1567. /[2]Singha PK, et al. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells. Eur J Pharm Sci. 2020 Apr 7;149:105321.

CAS Number: 13616-29-0

Molecular Weight: 554.60

Compound Purity: 99.0

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Fatty Acid Synthase (FASN)

• SKU: MEXHY-117769-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-117769-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK