GT-653

Product Description: GT-653 is a PROTAC degrader for lysine-specific demethylase 5B (KDM5B). GT-653 degrades 68.35% KDM5B at 10 μM in a ubiquitin proteasome-dependent manner, upregulates H3K4me3 levels, and activates the type-I interferon signaling pathway in prostate cancer cells 22RV1. (Pink: KDM5B ligand (HY-158433); Black: Linker (HY-W004896); Blue: E3 ligase ligand (HY-103596))[1]

Formula: C32H27N7O9

References: [1]Guan T, et al., Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer. Eur J Med Chem. 2024 May 10;272:116494. 

Molecular Weight: 653.60

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Histone Demethylase;PROTACs

• SKU: MEXHY-158432-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158432-0
• Package Unit: Get quote
• Quantity Unit: STK