Product Description: hAChE/hBACE-1-IN-4 (compound AK-2) is a quinazoline derivative. hAChE/hBACE-1-IN-4 shows significant inhibitory activity against hAChE and hBACE-1 enzymes (hAChE, IC50=0.283 μM; hBACE-1, IC50=0.231 μM). hAChE/hBACE-1-IN-4 has the potential to inhibit Aβ aggregation. hAChE/hBACE-1-IN-4 has non-neurotoxicity , blood-brain barrier permeability and oral activity. hAChE/hBACE-1-IN-4 can be used in Alzheimer's disease research[1].
Applications: Neuroscience-Neurodegeneration
Formula: C21H24N4O2
References: [1]Verma A, Waiker D K, Singh N, et al. Lead optimization based design, synthesis, and pharmacological evaluation of quinazoline derivatives as multi-targeting agents for Alzheimer’s disease treatment[J]. European Journal of Medicinal Chemistry, 2024: 116450.
CAS Number: 229476-71-5
Molecular Weight: 364.44
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Amyloid-β;Cholinesterase (ChE)
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