Product Description: HPK1-IN-45 (Compound 3) is a HPK1 inhibitor, with an IC50 of 0.3 nM. HPK1-IN-45 inhibits SLP-76 phosphorylation (IC50 = 57.52 nM) and IL-2 release (IC50 = 38 nM). HPK1-IN-45 can be used for the research of cancer[1].
Formula: C30H29N5O3
References: [1]Sun GL, et al. Hpk1 inhibitor, preparation method therefor, and use thereof. WO2024061345A1.
Molecular Weight: 507.58
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: MAP4K