HPO-DAEE, CAS 1895934-61-8

Product Description: HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways[1].

Formula: C12H22O4

References: [1]Inoue Y, et al. 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways. Neurochem Int. 2018 Jan;112:288-296.

CAS Number: 1895934-61-8

Molecular Weight: 230.30

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: HDAC;Reactive Oxygen Species;SOD

• SKU: MEXHY-158205-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158205-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK