Product Description: HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1(IC50=0.5 nM) and HSV-2(IC50=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection[1].
Formula: C21H19F2N3O3S2
References: [1]Gege C, et al. Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129761.