HTH-02-006

Product Description: HTH-02-006 is a NUAK2 inhibitor (IC50?=?126?nM). HTH-02-006 reduces levels of phosphorylated MYPT1 in HuCCT-1 cells. HTH-02-006 inhibits YAP-driven cell proliferation, hepatomegaly and tumorigenesis. HTH-02-006 also has antifibrotic protective effect[1][2].

Formula: C25H29IN6O3

References: [1]Zhang T, et al. NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling. Sci Transl Med. 2022 Mar 23;14(637):eaaz4028./[2]Yuan WC, et al. NUAK2 is a critical YAP target in liver cancer. Nat Commun. 2018 Nov 16;9(1):4834.

Molecular Weight: 588.44

Compound Purity: 99.49

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: AMPK

• SKU: MEXHY-156397-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156397-10.1
• Green Labware: No
• Package Unit: 10mM/1mL
• Quantity Unit: STK