IRAK4-IN-14, CAS 2667681-71-0

Product Description: IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 µM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib[1].

Applications: Cancer-Kinase/protease

Formula: C25H28FN9O

References: [1]Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815.

CAS Number: 2667681-71-0

Molecular Weight: 489.55

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: IRAK

• SKU: MEXHY-146112-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-146112-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK