K-8012, CAS 1346513-17-4

Product Description: K-8012, a sulindac (HY-B0008) analog, is a potent antagonist of RXRa. The IC50 value for K-8012 to inhibit 9-cis-RA-induced Gal4-RXRa-LBD trans-activation were about 9.2 μM. K-8012 exerts improved anticancer activity over sulindac in a RXRa-dependent manner. K-8012 exhibits activity in inhibiting the tRXRa-mediated PI3K/AKT signaling pathway. K-8012 induces apoptosis and inhibits AKT activation by preventing tRXRa from binding to p85a[1].

Formula: C23H23FN4

References: [1]Chen L, et al. Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site. Chem Biol. 2014 May 22;21(5):596-607.

CAS Number: 1346513-17-4

Molecular Weight: 374.45

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Akt;Apoptosis;PI3K;RAR/RXR

• SKU: MEXHY-121435-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-121435-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK