Product Description: L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer[1][2].
Applications: Cancer-programmed cell death
Formula: C11H10N4OS
References: [1]Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008/[2]Devashree Jahagirdar, et al. Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa. Current Cancer Therapy Reviews, 2018, 14, 1-11.
CAS Number: 64232-83-3
Molecular Weight: 246.29
Compound Purity: 98.0
Research Area: Cancer
Solubility: DMSO : ≥ 33 mg/mL
Target: DNA/RNA Synthesis
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