LAVR-289

Product Description: LAVR-289 is a [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with broad-spectrum anti-DNA virus activity. LAVR-289 can inhibit the activity of the wild-type (TK+) of varicella-zoster virus (VZV), thymidine kinase VZV-defective strain, human cytomegalovirus (HCMV), vaccinia virus (VV), and human herpesvirus 1 (HSV-1) (TK-) with EC50 values of 3.5 nM, 18 nM, 21 nM, 50 nM, and 8.5 nM, respectively[1].

Formula: C34H61N4O10P

References: [1]Bessières M, et al. Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses. Eur J Med Chem. 2024;271:116412.

Molecular Weight: 716.84

Research Area: Infection

Solubility: 10 mM in DMSO

Target: HSV

• SKU: MEXHY-163525-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163525-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK