LBA-3, CAS 2918263-09-7

Product Description: LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable[1].

Formula: C18H18O5

References: [1]Zhang L, et al., Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia. J Med Chem. 2024 Apr 25;67(8):6687-6704.

CAS Number: 2918263-09-7

Molecular Weight: 314.33

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Sodium Channel

• SKU: MEXHY-158160-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158160-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK