Product Description: Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602)[1][2].
Applications: Cancer-programmed cell death
Formula: C13H11BrN2O3
References: [1]Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17./[2]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
CAS Number: 2093387-36-9
Molecular Weight: 323.14
Compound Purity: 99.86
Research Area: Cancer
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Ligands for E3 Ligase
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