LLC0424

Product Description: LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand (HY-14658), Black: linker (HY-40002); Pink: NSD2 inhibitor (HY-161575))[1].

Formula: C45H41N7O9

References: [1]Lianchao Liu, et al. Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 May 9;67(9):6938-6951.

Molecular Weight: 823.85

Research Area: Cancer

Target: Histone Methyltransferase;PROTACs

• SKU: MEXHY-161574-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161574-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK