LTGO-33, CAS 2834106-06-6

Product Description: LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research[1].

Formula: C21H17F4N3O3S

References: [1]Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105(3):233-249.

CAS Number: 2834106-06-6

Molecular Weight: 467.44

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Sodium Channel

• SKU: MEXHY-157802-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-157802-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK