Product Description: ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC50=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes[1][2].
Applications: COVID-19-immunoregulation
Formula: C23H25N3O4S2
References: [1]Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41./[2]Eldstrom J, et al. ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state. J Gen Physiol. 2021 Dec 6;153(12):e202112969.
CAS Number: 1401242-74-7
Molecular Weight: 471.59
Compound Purity: 99.24
Research Area: Cardiovascular Disease
Solubility: DMSO : ≥ 56 mg/mL
Target: Potassium Channel
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