MNK1/2-IN-7, CAS 2548283-27-6

Product Description: MNK1/2-IN-7 (compound 20j) is an orally available inhibitor of MNK1/2 with anticancer activity and hERG safety. MNK1/2-IN-7 also inhibits the phosphorylation of eIF4E, inhibiting the MNK/eIF4E signaling pathway and cancer cell proliferation. MNK1/2-IN-7 is synergistic with Ibrutinib (HY-109970).[15][1].

Formula: C31H31N5O2

References: [1]Yuan X, et al. Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma[J]. Journal of Medicinal Chemistry, 2024.

CAS Number: 2548283-27-6

Molecular Weight: 505.61

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Eukaryotic Initiation Factor (eIF);MNK

• SKU: MEXHY-163479-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163479-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK