MTK458, CAS 2499962-58-0

Product Description: MTK458 is an orally active brain penetrant PINK1 activator. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 can be used for research on Parkinson's disease[1].

Applications: Cancer-programmed cell death

Formula: C17H15F3N4

References: [1]Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378.

CAS Number: 2499962-58-0

Molecular Weight: 332.32

Compound Purity: 99.28

Research Area: Cancer; Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Mitochondrial Metabolism;Mitophagy;PINK1/Parkin

• SKU: MEXHY-152943-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-152943-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK