Mutant IDH1/NAMPT-IN-1

Product Description: Mutant IDH1/NAMPT-IN-1 (Compound 23h) is a dual inhibitor of mutant isocitrate dehydrogenase 1 (mutant IDH1) (IC50=14.93 nM) and nicotinamide phosphoribosyltransferase (NAMPT) (IC50=12.56 nM). Mutant IDH1/NAMPT-IN-1 can induce apoptosis. Mutant IDH1/NAMPT-IN-1 crosses the blood-brain barrier effectively[1].

Applications: Cancer-programmed cell death

Formula: C30H29FN6O4

References: [1]Wen F, et al. Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation. J Med Chem. 2024 Apr 23.

Molecular Weight: 556.59

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Isocitrate Dehydrogenase (IDH);NAMPT

• SKU: MEXHY-158319-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158319-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK