Product Description: ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].
Applications: COVID-19-immunoregulation
Formula: C21H14F3N3O
References: [1]Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13(1):12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w
CAS Number: 2446880-46-0
Molecular Weight: 381.35
Compound Purity: 98.26
Research Area: Infection
Solubility: DMSO : 40 mg/mL (ultrasonic;adjust pH to 4 with 1 M HCL)
Target: Bacterial;Mitochondrial Metabolism
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