Nrf2-IN-3, CAS 6325-13-9

Product Description: Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex[1].

Formula: C22H26N4O4S

References: [1]Aboulkassim T, et al. A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Cell Rep. 2023 Sep 12;42(9):113104.

CAS Number: 6325-13-9

Molecular Weight: 442.53

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Keap1-Nrf2

• SKU: MEXHY-149508-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-149508-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK