NS 11021, CAS 956014-19-0

Product Description: NS 11021 is a potent and specific Ca2+-activated big-conductance K+ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].

Formula: C16H9BrF6N6S

References: [1]Bo Hjorth Bentzen, et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44/[2] Cagil Coskun, et al. BK channel openers NS1619 and NS11021 reverse hydrogen peroxide-induced membrane potential changes in skeletal muscle. J Recept Signal Transduct Res. 2020 Oct;40(5):449-455./[3]Stephen Shrum, et al. Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage-Induced Mitochondrial Injury In Vitro. Biomolecules. 2019 Dec 4;9(12):825.

CAS Number: 956014-19-0

Molecular Weight: 511.24

Compound Purity: 99.23

Research Area: Others

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Potassium Channel

• SKU: MEXHY-13103-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13103-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK