NS1643, CAS 448895-37-2

Product Description: NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells[1][2].

Formula: C15H10F6N2O3

References: [1]Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11./[2]Breuer EK, et al. Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling. Cell Death Dis. 2019 Feb 21;10(3):180.

CAS Number: 448895-37-2

Molecular Weight: 380.24

Compound Purity: 99.14

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: Autophagy;Potassium Channel

• SKU: MEXHY-16916-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16916-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK