NSCLC-IN-1

Product Description: NSCLC-IN-1 (Compound A10-2) induces mitophagy and ferroptosis through targeting transmembrane BAX inhibitor motif containing 6 (TMBIM6). NSCLC-IN-1 induces mitochondrial Ca2+ imbalance, leading to mitochondrial damage. NSCLC-IN-1 reduces intracellular glutathione (GSH), increases the accumulation of lipid peroxides (LPO) and malondialdehyde (MDA) content. NSCLC-IN-1 is a potent anti-NSCLC agent[1].

Applications: Cancer-programmed cell death

Formula: C46H56N2O13

References: [1]Wang Y, et al. 13-oxyingenol dodecanoate derivatives induce mitophagy and ferroptosis through targeting TMBIM6 as potential anti-NSCLC agents. Eur J Med Chem. 2024 Apr 15;270:116312.

Molecular Weight: 844.94

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Ferroptosis;Mitophagy

• SKU: MEXHY-161388-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161388-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK