NUDT5/14 antagonist 1

Product Description: NUDT5/14 antagonist 1 (Compound 9) is a selective, dual antagonist for nucleotide diphosphate kinase NUDT5 and NUDT14, with IC50 of 0.27 and 0.16 μM, respectively. NUDT5/14 antagonist 1 binds to Bruton’s tyrosine kinase (BTK) with an IC50 of 0.377 μM[1].

Applications: Cancer-Kinase/protease

Formula: C23H24N6O

References: [1]Balıkçı E, et al., Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. J Med Chem. 2024 May 9;67(9):7245-7259. 

Molecular Weight: 400.48

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: DNA/RNA Synthesis

• SKU: MEXHY-158318-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158318-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK