ONT-993, CAS 937263-81-5

Product Description: ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM)[1].

Applications: Cancer-programmed cell death

Formula: C26H24N8O3

References: [1]Sun H, et al. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl. Cancer Chemother Pharmacol. 2022 Jun;89(6):737-750.

CAS Number: 937263-81-5

Molecular Weight: 496.52

Compound Purity: 95.13

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Cytochrome P450

• SKU: MEXHY-151239-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-151239-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK