PAD4-IN-4

Product Description: PAD4-IN-4 (compound 28) is a potent PAD4 inhibitor (IC50=0.79 ± 0.09 μM). PAD4-IN-4 improves the tumor immune microenvironment by reshaping neutrophil phenotype, upregulating the proportions of dendritic cells and M1 macrophages, and reducing the amount of myeloid-derived suppressor cells. PAD4-IN-4 can be used for Triple-negative breast cancer research[1].

Formula: C32H31ClN6O2

References: [1]Zhu D, et al. A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer[J]. Journal of Medicinal Chemistry, 2024.

Molecular Weight: 567.08

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Protein Arginine Deiminase

• SKU: MEXHY-162494-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162494-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK