PAN endonuclease-IN-2

Product Description: PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication[1].

Applications: COVID-19-anti-virus

Formula: C25H21Br2NO7

References: [1]Ruan J, et al. Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics. Bioorg Chem. 2024 Mar;144:107139.

Molecular Weight: 607.24

Research Area: Infection

Solubility: 10 mM in DMSO

Target: Influenza Virus

• SKU: MEXHY-158028-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158028-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK