pan-HCN-IN-1, CAS 1334308-63-2

Product Description: pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC50 of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices[1].

Formula: C23H37N3O2

References: [1]Harde E, et al., Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell Chem Biol. 2024 Mar 21;31(3):577-592.e23.

CAS Number: 1334308-63-2

Molecular Weight: 387.56

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: HCN Channel

• SKU: MEXHY-163455-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163455-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK