Product Description: PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib(HY-10129, IC50 (MDA-MB-436) >100 μM)[1].
Formula: C23H19BrN6O3S
References: [1]Xiaoyu Peng, et al. High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders. Eur J Med Chem. 2024 May 5:271:116405.