Product Description: PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM[1].
Formula: C24H29NO7
References: [1]Yi Zhang, et al. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. Arch Toxicol. 2014, 88, 1.
CAS Number: 1178583-17-9
Molecular Weight: 443.49
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;PERK