Product Description: PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].
Formula: C19H17ClN2O2
References: [1]Humphrey J M, et al. Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1[J]. MedChemComm, 2014, 5(9): 1290-1296.
CAS Number: 1798334-07-2
Molecular Weight: 340.80
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Phosphodiesterase (PDE)