PF-05214030, CAS 1669444-50-1

Product Description: PF-05214030 is a TRPV4 antagonist (IC50: 4 and 27nM for hTRPV4 and rTRPV4 respectively). PF-05214030 reverses the reduction in bladder capacity caused by intravesical infusion of a TRPV4 agonist[1][2].

Formula: C17H13Cl2FN2O4S

References: [1]Jiang Y, et al. Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy. J Hematol Oncol. 2022 Mar 24;15(1):34./[2]Sarah Skerratt, et al. The Discovery and Optimisation of a Highly Selective Series of TRPV4 Antagonists.

CAS Number: 1669444-50-1

Molecular Weight: 431.27

Research Area: Others

Solubility: 10 mM in DMSO

Target: TRP Channel

• SKU: MEXHY-160603-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-160603-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK