Product Description: Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC50 of 0.15 and 1.25 μM[1].
Formula: C71H99N17O19S2
References: [1]Hu B, et al., Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67(18):8810-7.
CAS Number: 186180-20-1
Molecular Weight: 1558.78
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: MDM-2/p53