Phosphodiesterase-IN-2

Product Description: Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models[1].

Formula: C32H27F3N6O2

References: [1]Yuan H, et al., Discovery of 3-trifluoromethyl-substituted pyrazoles as selective phosphodiesterase 10A inhibitors for orally attenuating isoprenaline-induced cardiac hypertrophy[J]. Chinese Chemical Letters, 2024: 109965.

Molecular Weight: 584.59

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Phosphodiesterase (PDE)

• SKU: MEXHY-161663-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161663-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK