PI3Kδ-IN-21

Product Description: PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model[1].

Formula: C19H16ClN9

References: [1]Yu M, et al. “Discovery of Novel Azaindoles as Potent and Selective PI3Kδ Inhibitors for Treatment of Multiple Sclerosis.” Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c00788. 16 May. 2024,

Molecular Weight: 405.84

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: PI3K

• SKU: MEXHY-158688-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158688-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK