Product Description: PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM)[1].
Applications: Cancer-programmed cell death
Formula: C27H36N6O3
References: [1]Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/
CAS Number: 2251709-89-2
Molecular Weight: 492.61
Compound Purity: 98.92
Research Area: Cancer
Solubility: 10 mM in DMSO/DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)