PLK1/BRD4-IN-2, CAS 2251709-89-2

Product Description: PLK1/BRD4-IN-2 (compound 15) is a BI-2536 (HY-50698) analog and dual inhibitor that targets both Polo-like kinase 1 (PLK1) and BRD4bromodomain (BRD4-BD1 IC50=28 nM, PLK1 IC50=40 nM)[1].

Applications: Cancer-programmed cell death

Formula: C27H36N6O3

References: [1]Liu S, et al. Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.https://pubmed.ncbi.nlm.nih.gov/30125504/

CAS Number: 2251709-89-2

Molecular Weight: 492.61

Compound Purity: 98.92

Research Area: Cancer

Solubility: 10 mM in DMSO/DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Epigenetic Reader Domain

• SKU: MEXHY-160557-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-160557-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK