Product Description: PLK1/BRD4-IN-3 (Compound 21) is a selective dual inhibitor for bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). PLK1/BRD4-IN-3 inhibits BRD4-BD1, PLK1 and BRDT-BD1, with IC50s of 0.059, 0.127 and 0.245 μM, respectively[1].
Formula: C31H43N7O3
References: [1]Liu S, et al., Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.
CAS Number: 2251709-91-6
Molecular Weight: 561.72
Compound Purity: 99.66
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Epigenetic Reader Domain;Polo-like Kinase (PLK)