PROTAC CRBN ligand-2

Product Description: PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC50 of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV[1].

Applications: Cancer-programmed cell death

Formula: C33H30N8O8

References: [1]Julie Vatté, et al. Biguanide-PROTACs: Modulating Mitochondrial Proteins in Pancreatic Cancer Cells. bioRxiv. 2024.05.

Molecular Weight: 666.64

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Ligands for E3 Ligase

• SKU: MEXHY-158152-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158152-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK