PROTAC EZH2 Degrader-2

Product Description: PROTAC EZH2 Degrader-2 (compound E-3P-MDM2), an EZH2 inhibitor, is a PROTAC composed of Tazemetostat (EPZ6438) and an E3 ligase system ligand. PROTAC EZH2 Degrader-2 degrades EZH2 in SU-DHL-6 cells in a dose-dependent manner, inhibits the expression of H3K27me3, and simultaneously degrades EED and SUZ12 proteins without affecting their mRNA levels. PROTAC EZH2 Degrader-2 has anti-cancer and anti-proliferative activity[1].

Applications: Cancer-programmed cell death

Formula: C77H93Cl2N13O12

References: [1]Xie H et al. Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma. Bioorg Chem. 2023 Nov;140:106762.

Molecular Weight: 1463.55

Compound Purity: 99.78

Research Area: cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Histone Methyltransferase;PROTACs

• SKU: MEXHY-157164-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-157164-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK