PROTAC PARP1 degrader, CAS 2369022-68-2

Product Description: PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

Applications: Cancer-programmed cell death

Formula: C58H63Cl2N11O10

References: [1]Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.

CAS Number: 2369022-68-2

Molecular Weight: 1145.09

Compound Purity: 99.32

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: PARP;PROTACs

• SKU: MEXHY-114324-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-114324-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK