PROTAC Sirt2 Degrader-1, CAS 2098487-75-1

Product Description: PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM)[1].

Applications: Cancer-programmed cell death

Formula: C40H40N10O8S2

References: [1]Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

CAS Number: 2098487-75-1

Molecular Weight: 852.94

Compound Purity: 98.71

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: PROTACs;Sirtuin

• SKU: MEXHY-103636-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103636-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK