PTK7/β-catenin-IN-2, CAS 902434-29-1

Product Description: PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM[1].

Formula: C30H34Cl2N6O

References: [1]Ganier L, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer[J]. ACS Chemical Biology, 2022, 17(5): 1061-1072.

CAS Number: 902434-29-1

Molecular Weight: 565.54

Compound Purity: 96.96

Research Area: cancer

Solubility: 10 mM in DMSO

Target: β-catenin

• SKU: MEXHY-160489-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-160489-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK