PTPN2/1-IN-3

Product Description: PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice.[4][1].

Applications: Cancer-programmed cell death

Formula: C14H18FN3O4S

References: [1]Zheng J, et al. Synthesis and structure-activity optimization of azepane-containing derivatives as PTPN2/PTPN1 inhibitors. Eur J Med Chem. 2024 Apr 15;270:116390.

Molecular Weight: 343.37

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Phosphatase

• SKU: MEXHY-162428-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162428-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK