(R)-SKBG-1, CAS 2955634-67-8

Formulation: A solid

Formal Name: (2R)-4-(2-chloroacetyl)-N-[(4-methoxyphenyl)methyl]-1-[(4-methoxyphenyl)sulfonyl]-2-piperazinecarboxamide

Purity: ≥95%

Formula Markup: C22H26ClN3O6S

Formula Weight: 496

Shelf life (days): 1460

CAS Number: 2955634-67-8

Notes: (R)-SKBG-1 is a degrader of mRNA encoding the androgen receptor (AR).{66893} It decreases mRNA levels of AR and AR splice variant seven (AR-V7) and protein levels of AR and AR-V7 in 22Rv1 prostate cancer cells when used at a concentration of 20 µM. (R)-SKBG-1 (20 µM) reduces protein levels of AR and AR-V7 in wild-type 22Rv1 cells but not in NONO-/- 22Rv1 cells, which lack the RNA-binding protein non-POU domain-containing octamer-binding protein (NONO). It increases the number of NONO nuclear foci and NONO-bound immature mRNA transcripts in 22Rv1 cells. (R)-SKBG-1 is cytotoxic to 22Rv1 cells (IC50 = 44 µM).

• SKU: CAY42091-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42091-1
• Package Unit: 1 mg
• Quantity Unit: STK