Product Description: RA-XII is bicyclic hexapeptidic glucoside , which exhibits antitumor and anti-inflammatory activity. RA-XII activates Akt-mTOR singaling pathway, inhibits the formation of autophagosomes, and thus suppresses autophagy. RA-XII induces apoptosis through AMPK/mTOR/P70S6K pathway. RA-XII inhibit metastasis via reducing cell adhesion and invasion in breast cancer cells. RA-XII attenuates anti-inflammatory efficacy against acute kidney injury through HO-1/Nrf2 pathway[1][2][3][4].
Formula: C46H58N6O14
References: [1]Wang J, et al., RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells. J Ethnopharmacol. 2021 Feb 10;266:113438./[2]Leung HW, et al., RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation. Sci Rep. 2015 Nov 23;5:16985. /[3]An X, et al., RA-XII exerts anti-oxidant and anti-inflammatory activities on lipopolysaccharide-induced acute renal injury by suppressing NF-κB and MAPKs regulated by HO-1/Nrf2 pathway. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2317-2323. /[4]Song L, et al., Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells. Molecules. 2017 Nov 11;22(11):1934.
CAS Number: 143343-98-0
Molecular Weight: 918.98
Research Area: Cancer; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Akt;Apoptosis;Autophagy;mTOR
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